Cooperative bimetallic catalysis: a new alternative for the formation of C-C bonds using unsaturated hydrocarbons as pro-nucleophiles

Abstract

Traditionally, transition metal catalyzed C-C bond forming reactions have been developed using pre-made organometallic reagents. These procedures are inherently limited to the availability and reactivity profiles of the reagent itself and entail the formation of a stoichiometric amount of inorganic salt as a reaction by-product. One of the major challenges in modern synthetic chemistry is the development of sustainable and atom-efficient C-C bond forming reactions. In this context, catalytic transformations using simple and abundant organic materials as latent organometallic equivalents under cooperative bimetallic catalysis provide more efficient and operationally simpler processes than when stoichiometric quantities of sensitive intermediates are required.