Abstract
Glycoproteins have attracted much attention in recent years because they are involved in fundamental biological processes. At the present moment, the mechanisms that allow the carbohydrate to modify the conformational equilibrium of the peptide backbone and viceversa remain to be elucidated, which is essential to discern how glycoproteins interact with their biological targets. On this basis, our group is working in the synthesis and the conformational analysis in aqueous solution of different model peptides and glycopeptides. The conformational analysis combines Nuclear Magnetic Resonance data with Molecular Dynamics simulations and DFT calculations.