Synthesis of 3D arene bioisosteres through photocatalytic methods

Abstract

Over the past decade, saturated bicyclic compounds have attracted significant interest in medicinal chemistry for the design of new pharmaceuticals. These three-dimensional (3D) architectures have proven to be effective bioisosteric replacements for planar arenes (2D), leading to new molecules with improved physicochemical and biological properties. In this context, photocatalysis has emerged as one of the key strategies for the development of novel synthetic routes that enable access to these complex structures in a more practical and accessible manner. This article provides an overview on the major advances in the field of photocatalysis for the construction and functionalization of saturated bicyclic compounds, as well as emerging directions and current challenges.