Nanomedicines based on metal-organic frameworks and plasmonic nanoparticles

Abstract

Plasmonic nanoparticle (PNP)-based metal–organic framework (MOF) composites have attracted significant attention across diverse fields, including biomedicine, sensing, and (photo)catalysis. In the biomedical arena, these nanocomposites have emerged as highly promising platforms for cancer therapy applications. The combination of the high porosity, structural and chemical tunability of MOFs with the outstanding optical properties of plasmonic nanoparticles has enabled the development of multifunctional nanomaterials capable of integrating efficient therapeutic and diagnostic functions within a single nanomedicine (theragnostic).

This review summarizes recent advances in the development of PNP@MOF nanoplatforms, discussing the main synthetic strategies employed for their preparation and highlighting their most relevant biomedical applications. Particular emphasis is placed on multimodal systems that combine therapeutic functionalities with advanced bioimaging techniques.