New horizons in asymmetric aminocatalysis

Abstract

In this work, we exposed a brief report about the development of the asymmetric aminocatalysis by using secondary-amines such as the initial enantioselective aldol reactions, the iminium activation, or the last organocatalytic tandem and cascade reactions. These pioneer works have opened a new research area in asymmetric catalysis in which is possible to developed new synthetic tools. The asymmetric aminocatalysis is currently being applied to the synthesis of drugs or bioactive compounds (e.g. Tamiflu®).