Abstract
The formation of biorreversible derivatives of drugs –prodrugs– can be recognized as a tool to improve the behaviour of drugs with various difficulties in their clinical use. The present work revises relevant examples of prodrugs used in therapy in Spain, often explaining their behaviour with very simple models, depending on the pKa of the functional groups present in the molecule, or their hydrophobicity values –log P–. In all the examples, calculated values have been used for these parameters, obtained using simple computational tools.