Organometallic compounds in an unusually high oxidation state. Use in the oxidative trifluoromethylation of arylboron derivatives

Abstract

Aromatic trifluoromethylation enabled by metal complexes is highly challenging yet extremely relevant for drug discovery and agrochemical design. First discovered in 2010, the oxidative trifluoromethylation represents an original approach to these valuable chemicals (aryl–CF3 ) and involves the key participation of late transition metals in high oxidation state, in particular coinage metals (CuIIICF3 and AgIIICF3 species). We herein provide a general overview on this topic, and compile the main contributions regarding the oxidative trifluoromethylation of arylboron derivatives mediated by well-defined CuIII and AgIII complexes.