Organocatalytic processes of enantioselective desymmetrization

Abstract

Asymmetric synthesis was born as a response of the scientific community to the preference of certain biologic systems through one enantiomer over the other. Historically, the generation of new bonds has been the preferred strategy to create the targeted chirality, while counterintuitive bond cleavage has been led a side in the preparation of new chiral molecules. Among the lasts, asymmetric deprotonation using lithium-based bases emerged as the preferred strategy. However, and to overcome certain drawbacks associated with those bases, organocatalysis has appeared as an alternative, showing promising results within enantioselective deprotonation methodologies.