Abstract
Based on the equivalence of bases observed by Chargaff and data obtained by X-ray diffraction of DNA fibers by Rosalind Franklin and Maurice Wilkins; in 1953 James Watson and Francis Crick postulated an accurate model for the three-dimensional structure of DNA explaining how genetic information could replicate exactly. In 1958, Meselson and Stahl confirm experimentally the Watson-Crick model of semiconservative DNA replication, radioactively marked nucleic acid Escherichia coli and checking the isotopic distribution in various replications.